Gunther Disease, also known as congenital erythropoietic porphyria (CEP), is an extremely rare genetic disorder affecting the production of heme, a vital component of red blood cells. While there are no direct synonyms for Gunther Disease, some terms used interchangeably to refer to this condition include porphyria cutanea tarda (PCT) and erythropoietic porphyria. Gunther Disease is characterized by severe sensitivity to light, resulting in blistering and scarring of the skin, as well as anemia and other systemic complications. Due to its rarity, Gunther Disease often requires specialized medical management and care. As research continues, advancements may lead to improved understanding and treatment options for this challenging disorder.