Variola Major Virus, commonly known as the smallpox virus, is a highly contagious and deadly infection responsible for several outbreaks in the past. It is a member of the Poxviridae family and can cause severe flu-like symptoms, skin rashes, and scarring, and even lead to death in some cases. Some synonyms for the Variola Major Virus include the following: smallpox virus, variola virus, human orthopoxvirus, and orthopoxvirus variola. The virus was eradicated globally in the late 1970s due to successful vaccination campaigns, demonstrating the effectiveness of preventive measures in controlling infectious diseases.